Mitogen Activated Protein (MAP) Kinase Signaling

The mitogen-activated protein (MAP) kinase cell signaling pathway promotes cell growth, proliferation, and survival. The MAP kinase pathway may be activated via several different routes, including upstream growth factor receptor tyrosine kinases and downstream mutations in pathway gene components.

MAPK Signaling

Figure 1. Binding of a growth factor (e.g., EGF, HGF) to the receptor tyrosine kinase (RTK) activates the receptor's activity. SRC binds to the receptor at its SH2 domain. Activation of the receptor tyrosine kinase triggers downstream phosphorylation and activation of (H-/K-/N-) RAS, (A-/B-/C-) RAF, MEK1/2 (MAP2K1), ERK1/2 (MAPK1). Ultimately, ERK (MAPK1) activation activates gene transcription that regulates cell growth and survival. Specific nodes in the pathway that are therapeutically actionable are noted. Click here to open a larger version of this image in a new window.

Upstream Pathways

Downstream Pathways

Diseases in Which Pathway is Aberrantly Activated

Therapies That Target This Pathway

Genes Involved in the Pathway

Last Updated: May 24, 2016

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