Receptor Tyrosine Kinase/Growth Factor Signaling

Receptor tyrosine kinase cell signaling pathways regulate a variety of cellular processes including cell growth, proliferation, differentiation, survival, gene transcription, metabolic regulation, and others. Receptor tyrosine kinase signaling pathways are activated by the binding of a ligand, such as a growth factor, to the receptor tyrosine kinase. Receptor tyrosine kinase signaling pathways are inhibited by complex negative feedback loops which function to attenuate the activated receptor signaling.

RTK Signal Color

Figure 1. Binding of a growth factor (e.g., EGF, HGF) to a receptor tyrosine kinase activates the receptor tyrosine kinase and typically causes the dimerization of the two receptor monomers. The receptors are activated by phosphorylation within their kinase domains. Once the receptor is turned on, numerous downstream pathways are activated including MAP kinase signaling, JAK/STAT signaling, and PI3K/AKT1/MTOR signaling. Specific nodes in the pathway that are therapeutically actionable are noted. Click here to open a larger version of this image in a new window.

Downstream Pathways

Diseases in Which Pathway is Aberrantly Activated

Therapies That Target This Pathway

Genes Involved in the Pathway

Last Updated: May 24, 2016

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