Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 (ZRSR2) is a gene that encodes for a member of the
spliceosome. The protein coded by this
gene associates with the U2 auxiliary
factor, which plays an important role in RNA
splicing (Gene 2014).
Spliceosome mutations are observed in MDS, chronic lymphocytic leukemia (CLL), AML, and
chronic myelomonocytic leukemia (CMML), and these mutations can cause abnormal expression
patterns of some genes involved in cancer pathogenesis (Chesnais et al.
Strickland, S.A., Kim, A.S. 2015.
My Cancer Genome
(Updated December 2015)
December 7, 2015
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