Ubiquitin specific peptidase 6 (USP6) is a gene that encodes a protein that functions as a deubiqutinase with ATP-independent isopeptidase activity that catalyzes its own deubiquitination. The protein promotes the plasma membrane localization of ARF6 and regulates ARF6-independent protein trafficking via endocytosis. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Modified: July 1, 2015

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