Tuberous sclerosis 1 (TSC1) encodes for a protein, hamartin, that interacts with a protein encoded by the TSC2 gene, tuberin (Genetics Home Reference 2013). TSC1 acts as a tumor suppressor, through regulation of the mTOR pathway, which is involved in cell proliferation (Genetics Home Reference 2013; Sjodahl et al. 2011).

TSC1 interacts with mTOR pathway proteins, and a bladder cancer patient’s TSC1-mutated tumor has been observed to be sensitive to the mTOR inhibitor everolimus (Iyer et al. 2012).

Related Pathways

Contributors: David Solit, M.D.

Suggested Citation: Solit, D. 2015. TSC1. My Cancer Genome (Updated December 2015)

Modified: December 7, 2015

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