TNF receptor-associated factor 2 (TRAF2) is a gene that encodes a protein that functions in mediating TNF signal transduction by interacting with TNF receptors. The protein is also important for TNF-alpha mediated activation of NF-kappaB and MAPK8/JNK. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as eye cancer, intestinal cancer, and lung cancer.

Modified: July 1, 2015

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