Genes

TP53

Tumor protein p53 (TP53) is a gene that codes for a tumor suppressor protein. The protein regulates expression of genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and changes in metabolism (Gene 2014). In cancer, TP53’s normal roles are not fulfilled, leading to cell survival, DNA damage, and cell proliferation. TP53 is the most frequently mutated gene in cancer; it is mutated in about half of all cancers (Genetics Home Reference 2014). TP53 is most frequently mutated in ovarian, colon, and esophageal cancers, although it is significantly mutated in many other cancer types (COSMIC).

Related Pathways

Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S.A., Kim, A.S. 2015. TP53. My Cancer Genome https://www.padiracinnovation.org/content/gene/tp53/ (Updated December 2015)

Modified: December 4, 2015

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