Tumor protein p53 (TP53) is a gene that codes for a tumor suppressor protein. The protein regulates expression
of genes involved in cell cycle arrest,
apoptosis, senescence, DNA repair, and
changes in metabolism (Gene
2014). In cancer, TP53’s normal roles are not fulfilled, leading to cell
survival, DNA damage, and cell proliferation. TP53 is the most frequently mutated gene in
cancer; it is mutated in about half of all cancers (Genetics Home Reference
2014). TP53 is most frequently mutated in ovarian, colon, and esophageal cancers,
although it is significantly mutated in many other cancer types (COSMIC).
Strickland, S.A., Kim, A.S. 2015.
My Cancer Genome
(Updated December 2015)
December 4, 2015
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