Genes

TNFAIP3

Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) is a gene that encodes a protein that functions as a zinc finger protein and ubiquitin-editing enzyme. The protein inhibits NF-kappa B activation and TNF-mediated apoptotic death. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

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