Transforming growth factor, beta receptor 1 (TGFBR1) is a gene that encodes a serine/threonine protein kinase that forms a heteromeric complex with TGF-beta Type II receptors when bound to the TGF-beta ligand. The protein functions in the transduction of the TGF-beta signal. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and peritoneal cancer.

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Modified: December 7, 2015

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