Tet methylcytosine dioxygenase 2 (TET2; also known as ten-eleven translocation 2) is a gene that codes for a protein involved in epigenetic
regulation of myelopoeisis (Gene 2014; Solary et al.
2014). TET2 is a tumor suppressor, and so in cancer, loss of TET2 function, which
can occur via TET2 mutation, TET2 deletion, or IDH1 or IDH2 mutation, can cause myeloid or
lymphoid transformations (Solary et al. 2014). Mutations in TET2 have
been found in MDS, AML, ALL, and other hematologic malignancies.
Strickland, S.A., Kim, A.S. 2015.
My Cancer Genome
(Updated December 2015)
December 4, 2015
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