Tet methylcytosine dioxygenase 1 (TET1) is a gene
that encodes a protein that functions as a
dioxygenase that catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine. The
protein is also involved in active DNA demethylation. Fusions, missense mutations, nonsense mutations, and silent mutations
are observed in cancers such as breast cancer, intestinal cancer, and ovarian cancer.
July 1, 2015
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