Telomerase reverse transcriptase (TERT) is a gene that encodes an enzymatic protein that possesses reverse transcriptase activity. The protein also functions as an RNA component that serves as a template for the telomere repeat TTAGGG. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as cancers of the central nervous system, liver cancer, and cancers of the urinary tract.

Modified: July 1, 2015

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