Transcription factor 7-llike 1 (T-cell specific, HMG-box) (TCF7L1) is a gene that encodes a protein that is activated by beta catenin, mediates the Wnt signaling pathway, and is antagonized by the TGF-beta signaling pathway. Missense mutations, silent mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as colon cancer, skin cancer, and biliary tract cancer.

Modified: August 28, 2015

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