Stromal antigen 2 (STAG2) is a gene that
codes for a subunit of the cohesin complex, which is involved in many cellular processes,
such as DNA double-strand break repair and
chromatid segregation during mitosis (Nasmyth and Haering 2009).
Mutations in STAG2 have been observed in MDS, AML, bladder cancer, and other cancers (Losada 2014;
Walter et al. 2013).
Inactivation of cohesin may be a cause of aneuploidy in cancer (Gene 2014; Losada 2014).
Strickland, S.A., Kim, A.S. 2015.
My Cancer Genome
(Updated December 2015)
December 4, 2015
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