Stromal antigen 2 (STAG2) is a gene that codes for a subunit of the cohesin complex, which is involved in many cellular processes, such as DNA double-strand break repair and chromatid segregation during mitosis (Nasmyth and Haering 2009). Mutations in STAG2 have been observed in MDS, AML, bladder cancer, and other cancers (Losada 2014; Walter et al. 2013). Inactivation of cohesin may be a cause of aneuploidy in cancer (Gene 2014; Losada 2014).​

Related Pathways

Contributors: Stephen A. Strickland, M.D., MSCI, Annette S. Kim, M.D., Ph.D.

Suggested Citation: Strickland, S.A., Kim, A.S. 2015. STAG2. My Cancer Genome (Updated December 2015)

Modified: December 4, 2015

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