Serine/arginine-rich splicing factor 2
(SRSF2) is a gene that codes for one of
the several serine/arginine-rich splicing
factors. SRSF2 is a member of the spliceosome and is involved in mRNA processing (Gene 2014).
Spliceosome mutations are observed in MDS, chronic lymphocytic leukemia (CLL), AML, and
chronic myelomonocytic leukemia (CMML), and these mutations can cause abnormal expression
patterns of some genes involved in cancer pathogenesis (Chesnais et al.
Strickland, S.A., Kim, A.S. 2015.
My Cancer Genome
(Updated December 2015)
December 7, 2015
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