Spectrin, alpha, erythrocytic 1 (SPTA1) is a gene
that encodes an actin crosslinking and molecular scaffold protein
that links the plasma membrane to the actin cytoskeleton. Missense mutations, synonymous mutations,
nonsense mutations, and frameshift deletions
are observed in cancers such as esophageal cancer, genital tract cancer, and endometrial cancer.
January 7, 2016
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