Son of sevenless homolog 1 (SOS1) is a gene
that encodes a protein that functions as a
guanine nucleotide exchange factor for Ras proteins.
The protein regulates RAS proteins by mediating the exchange of GTP to GDP. Missense
mutations, nonsense mutations, silent mutations,
frameshift deletions and insertions, and in-frame deletions are observed in cancers such as
endometrial cancer, intestinal cancer, and stomach cancer.
July 1, 2015
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