Structural maintenance of chromosomes 3 (SMC3) is a gene that encodes a protein that has the ability to function as an intracellular, nuclear, or secreted protein. In its nuclear form, the protein functions in the adhesion of sister chromatids during mitosis. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as intestinal cancer, parathyroid cancer, and stomach cancer.

Modified: July 1, 2015

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