SMAD family member 2 (SMAD2) is a gene
that encodes a protein that is a member of the
SMAD family. The protein functions as a signal
transducer and transcriptional regulator for several signaling pathways,
particularly the TGF-beta signaling pathway.
Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are
observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
December 4, 2015
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