Genes

RUNX1T1

Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1; also known as ETO) is a gene that encodes a protein that belongs to the myeloid translocation gene family. The protein functions in blocking hematopoietic differentiation by associating with the nuclear corepressor/histone deacetylase complex. Missense mutations, nonsense mutations, silent mutations, frameshift insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Modified: July 1, 2015

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