Ribophorin I (RPN1) is a gene that encodes
a membrane protein of the rough
endoplasmic reticulum that is a component of an N-oligosaccharyl transferase complex (Gene 2013a). In
cancer, rearrangements involving RPN1 have been observed in AML.
MDS1 and EVI1 complex locus (MECOM, also known as EVI1) is a gene that encodes a transcriptional regulator protein (Gene 2013b). In cancer,
rearrangements involving EVI1 have been observed in AML. Its role is also being investigated
in MDS and other cancers.
The RPN1-EVI1 fusion has been observed in AML and CML (Lee et al. 2010).
Seegmiller, A., Jagasia, M. 2013.
My Cancer Genome
(Updated June 2013)
June 4, 2013
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