Genes

RPN1-EVI1 (RPN1-MECOM)

Ribophorin I (RPN1) is a gene that encodes a membrane protein of the rough endoplasmic reticulum that is a component of an N-oligosaccharyl transferase complex (Gene 2013a). In cancer, rearrangements involving RPN1 have been observed in AML.

MDS1 and EVI1 complex locus (MECOM, also known as EVI1) is a gene that encodes a transcriptional regulator protein (Gene 2013b). In cancer, rearrangements involving EVI1 have been observed in AML. Its role is also being investigated in MDS and other cancers.

The RPN1-EVI1 fusion has been observed in AML and CML (Lee et al. 2010​).

Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S.

Suggested Citation: Seegmiller, A., Jagasia, M. 2013. RPN1-EVI1 (RPN1-MECOM). My Cancer Genome https://www.padiracinnovation.org/content/gene/rpn1-evi1/ (Updated June 2013)

Modified: June 4, 2013

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