Protein tyrosine kinase 2 (PTK2; also known as FAK) is a gene that encodes a cytoplasmic protein that is found in focal adhesions that form between cells situated around extracellular matrix constituents. The protein promotes cell growth and plays a role in intracellular signal transduction pathways that are activated in response to neural peptides or cellular interactions with the extracellular matrix. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Related Pathways

Modified: December 4, 2015

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