Protein tyrosine kinase 2 (PTK2; also known as FAK) is a gene
that encodes a cytoplasmic protein that is found in focal adhesions that form between cells
situated around extracellular matrix constituents. The protein promotes cell growth and plays a
role in intracellular signal transduction pathways that are activated in response to neural
peptides or cellular interactions with the extracellular matrix. Missense mutations, nonsense
mutations, silent mutations, and frameshift deletions are observed in cancers such as
endometrial cancer, intestinal cancer, and skin cancer.
December 4, 2015
Disclaimer: The information presented at padiracinnovation.org is compiled from sources
believed to be reliable. Extensive efforts have been made to make this information as accurate and as
up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed.
Despite our best efforts, this information may contain typographical errors and omissions. The contents
are to be used only as a guide, and health care providers should employ sound clinical judgment in
interpreting this information for individual patient care.