Genes

PTCH1

Patched 1 (PTCH1) is a gene that encodes a protein that belongs to the patched gene family. The protein functions as a receptor protein for sonic hedgehog, desert hedgehog, and indian hedgehog proteins. Fusions, missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions and insertions are observed in cancers such as bone cancer, skin cancer, and vulvar cancer.

Related Pathways

Modified: December 4, 2015

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