PC4 and SFRS1 interacting protein 1 (PSIP1) is a gene that encodes a protein that functions as a transcriptional co-activator that participates in neuroepithelial stem cell differentiation and neurogenesis. The protein may also play a critical role in lens epithelial to fiber cell differentiation and a protective role during stress-induced apoptosis. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and urinary tract cancer.

Modified: July 1, 2015

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