Genes

PRKAR1A

Protein kinase, cAMP-dependent, regulatory, type I, alpha (PRKAR1A) is a gene that encodes a protein that functions as a regulatory subunit of cAMP-dependent protein kinase. The protein is also a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as adrenal cancer, soft tissue cancer, and testicular cancer.

Modified: July 1, 2015

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