Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2) is a gene that encodes a protein that functions as a RAC1 guanine nucleotide exchange factor. Missense mutations, synonymous mutations, nonsense mutations, frameshift deletions, and frameshift insertions are observed in cancers such as colon cancer, esophageal cancer, and lung cancer.

Modified: January 7, 2016

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