POU class 2 associating factor 1 (POU2AF1) is a gene that encodes a protein that functions as a transcriptional co-activator that boosts OCT1 and OCT2 mediated promoter activity. The protein is also important for the B-cell response to antigens and the formation of germinal centers. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Modified: July 1, 2015

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