Genes

PML-RARA

Promyelocytic leukemia (PML), is a gene that encodes for a transcription factor and tumor suppressor protein (Gene 2013a). PML is involved in rearrangements observed in AML, particularly APL (acute promyelocytic leukemia).

Retinoic acid receptor, alpha (RARA) is a gene that encodes for a nuclear retinoic acid receptor, a transcription regulating protein (Gene 2013b). In cancer, rearrangements involving RARA have been observed in AML and APL. Its role is also being investigated in gastric and other cancers.

The PML-RARA fusion has been observed in most cases of APL.

Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S.

Suggested Citation: Seegmiller, A., Jagasia, M. 2013. PML-RARA. My Cancer Genome https://www.padiracinnovation.org/content/gene/pml-rara/ (Updated June 2013)

Modified: June 4, 2013

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