Pyruvate kinase, muscle (PKM) is a gene that encodes a protein that functions as an enzyme in glycolysis. The protein catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP in order to produce pyruvate and ATP. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as cervical cancer, endometrial cancer, and pituitary cancer.

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Modified: December 4, 2015

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