Genes

PIK3C3

Phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3) is a gene that encodes a protein that functions as a catalytic subunit of the PI3K protein complex. The protein facilitates the formation of phosphatidylinositol 3-phosphate – a protein that regulates the developmental stages of autophagosomes. The protein is also involved in the transport of lysosomal enzymes and cytokinesis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Modified: July 1, 2015

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