Genes

PDK1

Pyruvate dehydrogenase kinase, isozyme 1 (PDK1) is a gene that encodes a protein that functions in the catalysis of the oxidative decarboxylation of pyruvate. The enzyme also plays an important role in the regulation of homeostasis of carbohydrate fuels in animals. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as cervical cancer, endometrial cancer, and intestinal cancer.

Modified: July 1, 2015

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