Pyruvate dehydrogenase beta (PDHB) is a gene that encodes a protein that functions as an enzyme in the TCA cycle. The protein catalyzes the conversion of pyruvate to acetyl-CoA and CO2. Missense mutations, nonsense mutations, and silent mutations are observed in cancers such as cervical cancer, endometrial cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

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