Programmed cell death 1 ligand 2 (PDCD1LG2; also known as PDL2) is a gene that encodes a protein that functions in the costimulatory signal that is required for T-cell proliferation and IFNG production. The interaction of the protein with PDCD1 blocks T-cell proliferation. Fusions, missense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Modified: July 1, 2015

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.