Genes

PDCD1LG2

Programmed cell death 1 ligand 2 (PDCD1LG2; also known as PDL2) is a gene that encodes a protein that functions in the costimulatory signal that is required for T-cell proliferation and IFNG production. The interaction of the protein with PDCD1 blocks T-cell proliferation. Fusions, missense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Modified: July 1, 2015

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