Programmed cell death 1 (PDCD1) is a gene that encodes a cell surface membrane protein that belongs to the immunoglobulin superfamily. The protein functions in the differentiation of pro-B-cells. The protein may also be important for T-cell functioning and the prevention of autoimmune diseases. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Modified: July 1, 2015

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