Pre-B-cell leukemia homeobox 1 (PBX1) is a gene that encodes a nuclear protein that may function in the regulation of osteogenesis and skeletal patterning/programming.  A chromosomal translocation resulting in a fusion protein contributes to the development of pre-B-cell acute lymphoblastic leukemia. Fusions, missense mutations, and silent mutations are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

Modified: July 1, 2015

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