The p21 protein (Cdc42/Rac)-activated kinase 3 (PAK3) gene encodes a serine/threonine kinase protein that activates p21 and links Rho GTPases to cytoskeleton reorganization and nuclear signaling processes. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and lung cancer.

Modified: July 1, 2015

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