Notch 2 (NOTCH2) is a gene that
encodes a transmembrane protein that functions
in multiple developmental processes and the interactions between adjacent cells. The
transmembrane protein also functions as a
receptor for membrane bound ligands. Missense
mutations, nonsense mutations, silent mutations,
and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin
cancer, and cancers of the urinary tract.
July 1, 2015
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