Nuclear factor, erythroid 2-like 2 (NFE2L2) is a gene that encodes a transcription factor protein that is a member of a family of leucine zipper proteins. The protein functions in the regulation of antioxidant response elements that promote immunological responses such as inflammation. Missense mutations, nonsense mutations, silent mutations, and in-frame insertions and deletions are observed in cancers such as esophageal cancer, liver cancer, and lung cancer.

Modified: July 1, 2015

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