Nicastrin (NCSTN) is a gene that encodes a protein that cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein. Missense mutations, synonymous mutations, nonsense mutations, and frameshift mutations are observed in cancers such as stomach cancer, colon cancer, and urinary tract cancer.

Modified: January 7, 2016

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.