Genes

MTOR

Mechanistic target of rapamycin (MTOR) is a gene that encodes a family of phosphatidylinositol kinase-related kinases. Activating MTOR mutations increase the kinase activity of MTOR, leading to hyperactivation of downstream pro-survival signaling pathways. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are also observed. MTOR mutations are observed in cancers such as breast cancer, lung cancer, ovarian cancer, and skin cancer. 

Related Pathways

Modified: December 4, 2015

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