Megakaryoblastic leukemia (translocation) 1 (MKL1) is a gene that encodes a protein that functions in the interaction with myocardin – a transcription factor and regulator of smooth muscle differentiation. The protein may also perpetuate cell signals from the cytoskeleton to the nucleus. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.