Megakaryoblastic leukemia (translocation) 1 (MKL1) is a gene that encodes a protein
that functions in the interaction with myocardin – a transcription
factor and regulator of smooth muscle differentiation. The protein
may also perpetuate cell signals from the cytoskeleton to the nucleus. Fusions, missense mutations, nonsense mutations, silent mutations,
frameshift deletions and insertions, and in-frame insertions are observed in cancers such as
intestinal cancer, skin cancer, and stomach cancer.
December 4, 2015
Disclaimer: The information presented at padiracinnovation.org is compiled from sources
believed to be reliable. Extensive efforts have been made to make this information as accurate and as
up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed.
Despite our best efforts, this information may contain typographical errors and omissions. The contents
are to be used only as a guide, and health care providers should employ sound clinical judgment in
interpreting this information for individual patient care.