Genes

MIB1

Mindbomb E3 ubiquitin protein ligase 1 (MIB1) is a gene that encodes a protein that functions as an E3 ubiquitin ligase. The protein positively regulates NOTCH signaling via ubiquitination of the Notch receptors. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as breast cancer, lung cancer, and skin cancer.

Modified: July 1, 2015

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