Mediator complex subunit 12 (MED12) is a gene
that encodes a protein that is a member of a
CDK8 protein complex that binds to a component
of the preinitiation complex that functions in protein
assembly. The protein encoded by this gene functions in the regulation of transcription. Missense mutations, nonsense mutations,
silent mutations, frameshift insertions and
deletions, and in-frame deletions and insertions are observed in cancers such as breast cancer,
endometrial cancer, and lung cancer.
July 1, 2015
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