Mitogen-activated protein kinase kinase kinase 6 (MAP3K6) is a gene that encodes a protein that functions as a serine/threonine kinase. The protein is involved in kinase-mediated signal transduction cascades and the regulation of vascular endothelial growth factor (VEGF) expression. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as breast cancer, lung cancer, and ovarian cancer.

Modified: July 1, 2015

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