Mitogen-activated protein kinase kinase 2 (MAP2K2) is a gene that encodes a protein that is a member of the MAP kinase kinase family. The protein functions as a dual specificity protein kinase that regulates mitogen growth factor signal transduction by phosphorylating and activating MAPK1/ERK2 and MAPK2/ERK3. Missense and silent mutations are observed in cancers such as bone cancer, skin cancer, and stomach cancer.

Related Pathways

Modified: December 4, 2015

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.