MEK1 (also known as MAP2K1) is a serine-threonine protein
kinase that is a central mediator in the
MAP kinase signaling pathway. As part of the MAP kinase pathway, MEK1 is involved in many
cellular processes, including cell proliferation, differentiation, and transcriptional
Figure 1. Schematic of the MAPK and PI3K
pathways. Growth factor binding to receptor
tyrosine kinase results in activation of
the MAPK signaling pathway
(RAS-RAF-MEK-ERK) and the PI3K pathway (PI3K-AKT-mTOR). The letter "K" within the schema
denotes the tyrosine kinase domain.
Lovly, C.M., Horn, L., Pao, W. 2017.
My Cancer Genome
(Updated February 2017)
February 16, 2017
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