V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF) is a gene that encodes a protein that, depending on the binding site and binding partner, functions as a transcriptional activator or repressor. The protein is also involved in the regulation of cellular processes such as embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Fusions, missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as intestinal cancer, stomach cancer, and urinary tract cancer.

Modified: July 1, 2015

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