Lymphoid enhancer-binding factor 1 (LEF1) is a gene that encodes a transcription factor protein that functions in binding to a site in the T-cell receptor-alpha enhancer to maximize enhancer activity. The protein may also play a role in hair cell differentiation and follicle morphogenesis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, meningeal cancer, and stomach cancer.

Modified: July 1, 2015

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