Lactate dehydrogenase B (LDHB) is a gene that encodes a protein that functions as an enzyme in the glycolytic pathway. The protein catalyzes the reversible conversion of lactate and NAD to pyruvate and NADH—a reversible reaction. Missense mutations, nonsense mutations, silent mutations, and nonstop extensions are observed in cancers such as bone cancer, intestinal cancer, and skin cancer.

Related Pathways

Modified: December 4, 2015

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