KMT2A-MLLT3 is a fusion between the KMT2A (lysine (K)-specific methyltransferase 2A, also known as MLL) gene and the MLLT3 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3) gene. The KMT2A-MLLT3 fusion has been observed in AML and B lymphoblastic leukemia/lymphoma (Takachi et al. 2011; Metzler et al. 2004). The KMT2A-MLLT3 fusion gene, t(9;11)(p22;q23), results in a protein that prevents normal maturation of hematopoietic cells (Mueller et al. 2009). However, additional mutations are likely required for leukemogenesis (Pession et al. 2003).

Related Pathways

Modified: December 4, 2015

Disclaimer: The information presented at is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.